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Prospective Study of Endogenous Tissue Plasminogen Activator and Risk of Stroke Lancet 343:940-943, Ridker,P.M.,et al, 1994 See this aricle in Pubmed Article Abstract To find out whether a marker of endogenous fibrinolytic function might be associated with stroke risk,we measured tissue plasminogen activator(tPA) antigen concentrations in baseline plasma samples from 88 healthy participants in the Physicians'Health Study who subsequently had first- ever strokes(71 thromboembolic,12 hemorrhagic,5 indeterminate)and from 471 participants who remained free of cardiovascular disease during 5 years of followup(controls).This prospective study shows that high concentrations of tPA antigen among apparently healthy men are independently associated with high risks of future stroke,especially thromboembolic stroke.This finding is consistent with the hypothesis that activation of the endogenous fibrinolytic system occurs years in advance of arterial vascular occlusion.

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(click to filter results - removes previous filter) carotid artery atherosclerosis carotid artery disease cerebrovascular accident cerebrovascular accident,circadian rhythm cerebrovascular accident,prevention of cerebrovascular disease cerebrovascular disease,risk factors in circadian rhythm fibrinolytic agents risk factors tissue plasminogen activator,intravenous

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